{"id":13829,"date":"2021-11-05T09:01:42","date_gmt":"2021-11-05T09:01:42","guid":{"rendered":"https:\/\/assignmenttutors.net\/blog\/?p=13829"},"modified":"2021-11-05T09:01:42","modified_gmt":"2021-11-05T09:01:42","slug":"alzhemeirs-disease","status":"publish","type":"post","link":"https:\/\/assignmenttutors.net\/blog\/alzhemeirs-disease\/","title":{"rendered":"Alzhemeir&#8217;s Disease"},"content":{"rendered":"<p>Alzheimer\u2019s disease (AD) is a progressive\u00a0neurodegenerative\u00a0disorder characterized by memory loss and cognitive dysfunction. It has been shown that\u00a0stellate\u00a0cells\u00a0in the medial\u00a0entorhinal\u00a0cortex (MEC) (a major component for the grid cells!) appear to be selectively vulnerable to pathology and cell death in AD patients.<br \/>\nNow, if we want to study the deterioration of spatial coding in the MEC over the development of AD pathology (usually months) in a mouse model, which technology will you choose? How would you design the experiments (hint:\u00a0how to assess spatial coding specifically in\u00a0stellate\u00a0cells, and how to examine deterioration)? What would be the major concerns of using this technology in this scenario? Please answer each question with a few sentences.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alzheimer\u2019s disease (AD) is a progressive\u00a0neurodegenerative\u00a0disorder characterized by memory loss and cognitive dysfunction. It has been shown that\u00a0stellate\u00a0cells\u00a0in the medial\u00a0entorhinal\u00a0cortex (MEC) (a major component for the grid cells!) appear to be selectively vulnerable to pathology and cell death in AD patients. Now, if we want to study the deterioration of spatial coding in the MEC [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-13829","post","type-post","status-publish","format-standard","hentry","category-healthcare-medicine-nursing"],"_links":{"self":[{"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/posts\/13829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/comments?post=13829"}],"version-history":[{"count":2,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/posts\/13829\/revisions"}],"predecessor-version":[{"id":13831,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/posts\/13829\/revisions\/13831"}],"wp:attachment":[{"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/media?parent=13829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/categories?post=13829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/assignmenttutors.net\/blog\/wp-json\/wp\/v2\/tags?post=13829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}